Polypharmacy in elective lumbar spinal surgery for degenerative conditions with 24-month follow-up

Polypharmacy in elective lumbar spinal surgery for degenerative conditions with 24-month follow-up

  • Welsh, T. P., Yang, A. E. & Makris, U. E. Musculoskeletal Pain in older adults: A clinical review. Med. Clin. North. Am. 104, 855–872. (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Bressler, H. B., Keyes, W. J., Rochon, P. A. & Badley, E. The prevalence of low back pain in the elderly. A systematic review of the literature. Spine (Phila Pa. 1976). 24, 1813–1819. (1999).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Palmer, K. T. & Goodson, N. Ageing, musculoskeletal health and work. Best Pract. Res. Clin. Rheumatol. 29, 391–404. (2015).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Woolf, A. D. & Pfleger, B. Burden of major musculoskeletal conditions. Bull. World Health Organ. 81, 646–656 (2003).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Podichetty, V. K., Mazanec, D. J. & Biscup, R. S. Chronic non-malignant musculoskeletal pain in older adults: clinical issues and opioid intervention. Postgrad. Med. J. 79, 627–633. (2003).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Patel, K. V., Guralnik, J. M., Dansie, E. J. & Turk, D. C. Prevalence and impact of pain among older adults in the United States: Findings from the 2011 National Health and Aging trends Study. Pain. 154, 2649–2657. (2013).

    Article 
    PubMed 

    Google Scholar 

  • Rudy, T. E., Weiner, D. K., Lieber, S. J., Slaboda, J. & Boston, R. J. The impact of chronic low back pain on older adults: A comparative study of patients and controls. Pain. 131, 293–301. (2007).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Rundell, S. D. et al. Predictors of persistent disability and back pain in older adults with a new episode of care for back pain. Pain Med. 18, 1049–1062. (2017).

    Article 
    PubMed 

    Google Scholar 

  • Vos, T. et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: A systematic analysis for the global burden of Disease Study 2010. Lancet. 380, 2163–2196. (2012).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Peck, J. et al. A comprehensive review of over the counter treatment for chronic low back pain. Pain Ther. 10, 69–80. (2021).

    Article 
    PubMed 

    Google Scholar 

  • Schoenfeld, A. J. & Weiner, B. K. Treatment of lumbar disc herniation: evidence-based practice. Int. J. Gen. Med. 3, 209–214. (2010).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Chaparro, L. E. et al. Opioids compared to placebo or other treatments for chronic low-back pain. Cochrane Database Syst. Rev. CD004959 (2013).

  • Frazier, S. C. Health outcomes and polypharmacy in elderly individuals: An integrated literature review. J. Gerontol. Nurs. 31, 4–11. (2005).

    Article 
    PubMed 

    Google Scholar 

  • Nguyen, J. K., Fouts, M. M., Kotabe, S. E. & Lo, E. Polypharmacy as a risk factor for adverse drug reactions in geriatric nursing home residents. Am. J. Geriatr. Pharmacother. 4, 36–41. (2006).

    Article 
    PubMed 

    Google Scholar 

  • Akazawa, M., Imai, H., Igarashi, A. & Tsutani, K. Potentially inappropriate medication use in elderly Japanese patients. Am. J. Geriatr. Pharmacother. 8, 146–160. (2010).

    Article 
    PubMed 

    Google Scholar 

  • Dagli, R. J. & Sharma, A. Polypharmacy: A global risk factor for elderly people. J. Int. Oral Health. 6, i–ii (2014).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Harstedt, M., Rogmark, C., Sutton, R., Melander, O. & Fedorowski, A. Polypharmacy and adverse outcomes after hip fracture surgery. J. Orthop. Surg. Res. 11, 151. (2016).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Onder, G., Marengoni, A. & Polypharmacy JAMA 318, 1728, (2017).

    Article 
    PubMed 

    Google Scholar 

  • Masnoon, N., Shakib, S., Kalisch-Ellett, L. & Caughey, G. E. What is polypharmacy? A systematic review of definitions. BMC Geriatr. 17, 230. (2017).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Kantor, E. D., Rehm, C. D., Haas, J. S., Chan, A. T. & Giovannucci, E. L. Trends in prescription drug use among adults in the United States from 1999–2012. JAMA. 314, 1818–1831. (2015).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Will, J. S., Bury, D. C. & Miller, J. A. Mechanical low back pain. Am. Fam Physician. 98, 421–428 (2018).

    PubMed 

    Google Scholar 

  • Wong, A. Y. L., Karppinen, J. & Samartzis, D. Low back pain in older adults: Risk factors, management options and future directions. Scoliosis Spinal Disord. 12, 14. (2017).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Dietz, N., Wagers, S., Harkema, S. J. & D’Amico, J. M. Intrathecal and oral baclofen use in adults with spinal cord Injury: A systematic review of efficacy in spasticity reduction, functional changes, dosing, and adverse events. Arch. Phys. Med. Rehabil. 104, 119–131. (2023).

    Article 
    PubMed 

    Google Scholar 

  • Corsonello, A., Pedone, C. & Incalzi, R. A. Age-related pharmacokinetic and pharmacodynamic changes and related risk of adverse drug reactions. Curr. Med. Chem. 17, 571–584. (2010).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Sato, K. et al. Prescription drug survey of elderly patients with degenerative musculoskeletal disorders. Geriatr. Gerontol. Int. 22, 121–126. (2022).

    Article 
    PubMed 

    Google Scholar 

  • Kwan, G. T., Frable, B. W., Thompson, A. R. & Tresguerres, M. Optimizing immunostaining of archival fish samples to enhance museum collection potential. Acta Histochem. 124, 151952. (2022).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Cadel, L. et al. Spinal cord injury and polypharmacy: a scoping review. Disabil. Rehabil. 42, 3858–3870. (2020).

    Article 
    PubMed 

    Google Scholar 

  • Hansen, L. IBM MarketScan research databases for life sciences researchers. IBM Watson Health (2018).

  • Kitzman, P., Cecil, D. & Kolpek, J. H. The risks of polypharmacy following spinal cord injury. J. Spinal Cord Med. 40, 147–153. (2017).

    Article 
    PubMed 

    Google Scholar 

  • Quan, H. et al. Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data. Med. Care. 43, 1130–1139. (2005).

    Article 
    PubMed 

    Google Scholar 

  • Armstrong, R. A. When to use the bonferroni correction. Ophthalmic Physiol. Opt. 34, 502–508. (2014).

    Article 
    PubMed 

    Google Scholar 

  • Ranstam, J. Multiple P-values and Bonferroni correction. Osteoarthr. Cartil. 24, 763–764. (2016).

    Article 
    CAS 

    Google Scholar 

  • Hales, C. M., Servais, J., Martin, C. B. & Kohen, D. Prescription drug use among adults aged 40–79 in the United States and Canada. NCHS Data Brief., 1–8 (2019).

  • Halli-Tierney, A. D., Scarbrough, C. & Carroll, D. Polypharmacy: Evaluating risks and deprescribing. Am. Fam Physician. 100, 32–38 (2019).

    PubMed 

    Google Scholar 

  • Delara, M. et al. Prevalence and factors associated with polypharmacy: A systematic review and Meta-analysis. BMC Geriatr. 22, 601. (2022).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • O’Mahony, D. & Rochon, P. A. Prescribing cascades: we see only what we look for, we look for only what we know. Age Ageing. 51 (2022).

  • Pietraszek, A. et al. Sociodemographic and Health-related factors influencing drug intake among the Elderly Population. Int. J. Environ. Res. Public. Health. 19 (2022).

  • Slater, N., White, S., Venables, R. & Frisher, M. Factors associated with polypharmacy in primary care: A cross-sectional analysis of data from the English Longitudinal Study of Ageing (ELSA). BMJ Open. 8, e020270. (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Midao, L., Giardini, A., Menditto, E., Kardas, P. & Costa, E. Polypharmacy prevalence among older adults based on the survey of health, ageing and retirement in Europe. Arch. Gerontol. Geriatr. 78, 213–220. (2018).

    Article 
    PubMed 

    Google Scholar 

  • Fu, J. L. & Perloff, M. D. Pharmacotherapy for spine-related pain in older adults. Drugs Aging. 39, 523–550. (2022).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Lee, V. W. et al. Medication adherence: Is it a hidden drug-related problem in hidden elderly? Geriatr. Gerontol. Int. 13, 978–985. (2013).

    Article 
    PubMed 

    Google Scholar 

  • Hanlon, J. T. et al. Incidence and predictors of all and preventable adverse drug reactions in frail elderly persons after hospital stay. J. Gerontol. Biol. Sci. Med. Sci. 61, 511–515. (2006).

    Article 

    Google Scholar 

  • Dietz, N. et al. Preoperative and postoperative opioid dependence in patients undergoing Anterior Cervical Diskectomy and Fusion for degenerative spinal disorders. J. Neurol. Surg. Cent. Eur. Neurosurg. 82, 232–240. (2021).

    Article 

    Google Scholar 

  • Sharma, M. et al. Impact of Surgical approaches on complications, Emergency Room Admissions, and Health Care Utilization in patients undergoing lumbar fusions for degenerative disc diseases: a MarketScan Database Analysis. World Neurosurg. 145, e305–e319. (2021).

    Article 
    PubMed 

    Google Scholar 

  • Dietz, N. et al. Cannabis Use Disorder trends and Health Care utilization following cervical and lumbar spine fusions. Spine (Phila Pa. 1976). (2023).

    Article 
    PubMed 

    Google Scholar 

  • Dublin, S. et al. Use of opioids or benzodiazepines and risk of pneumonia in older adults: A population-based case-control study. J. Am. Geriatr. Soc. 59, 1899–1907. (2011).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Zhou, J. et al. Incidence of Surgical site infection after spine surgery: A systematic review and Meta-analysis. Spine (Phila Pa. 1976). 45, 208–216. (2020).

    Article 
    PubMed 

    Google Scholar 

  • Dietz, N. et al. Health Care utilization and Associated Economic Burden of Postoperative Surgical Site infection after spinal surgery with Follow-Up of 24 months. J. Neurol. Surg. Cent. Eur. Neurosurg. 84, 21–29. (2023).

    Article 

    Google Scholar 

  • Dietz, N. et al. Outcomes of decompression and fusion for treatment of spinal infection. Neurosurg. Focus. 46, E7. (2019).

    Article 
    PubMed 

    Google Scholar 

  • Zhang, L. & Li, E. N. Risk factors for surgical site infection following lumbar spinal surgery: A meta-analysis. Ther. Clin. Risk Manag. 14, 2161–2169. (2018).

    Article 
    ADS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Chilakapati, S., Burton, M. D. & Adogwa, O. Preoperative polypharmacy in geriatric patients is Associated with increased 90-Day all-cause hospital readmission after surgery for adult spinal deformity patients. World Neurosurg. 164, e404–e410. (2022).

    Article 
    PubMed 

    Google Scholar 

  • Holden, T. R., Kushner, B. S., Hamilton, J. L., Han, B. & Holden, S. E. Polypharmacy is predictive of postoperative complications in older adults undergoing ventral hernia repair. Surg. Endosc. 36, 8387–8396. (2022).

    Article 
    PubMed 

    Google Scholar 

  • Abe, N. et al. Polypharmacy at admission prolongs length of hospitalization in gastrointestinal surgery patients. Geriatr. Gerontol. Int. 20, 1085–1090. (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Arends, B. C. et al. The association of polypharmacy with functional decline in elderly patients undergoing cardiac surgery. Br. J. Clin. Pharmacol. 88, 2372–2379. (2022).

    Article 
    PubMed 

    Google Scholar 

  • Nazemi, A. K. et al. Prevention and management of postoperative delirium in elderly patients following elective spinal surgery. Clin. Spine Surg. 30, 112–119. (2017).

    Article 
    PubMed 

    Google Scholar 

  • Hein, C. et al. Impact of polypharmacy on occurrence of delirium in elderly emergency patients. J. Am. Med. Dir. Assoc. 15 (850 e811-855). (2014).

  • Ranhoff, A. H. et al. Delirium in a sub-intensive care unit for the elderly: Occurrence and risk factors. Aging Clin. Exp. Res. 18, 440–445. (2006).

    Article 
    PubMed 

    Google Scholar 

  • Sharma, M. et al. Incidence of new onset dementia and health care utilization following spine fusions: A propensity score matching analysis. Neurochirurgie. 68, 562–568. (2022).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Sharma, M. et al. Trends and outcomes in patients with dementia undergoing spine fusions: A matched nationwide inpatient sample analysis. World Neurosurg. 169, e164–e170. (2023).

    Article 
    PubMed 

    Google Scholar 

  • Lertkovit, S. et al. Polypharmacy in older adults undergoing major surgery: Prevalence, Association with postoperative cognitive dysfunction and potential Associated Anesthetic agents. Front. Med. (Lausanne). 9, 811954. (2022).

    Article 
    PubMed 

    Google Scholar 

  • Lee, S. W. et al. Opioid utility and hospital outcomes among inpatients admitted with Osteoarthritis and Spine disorders. Am. J. Phys. Med. Rehabil. (2022).

    Article 
    PubMed 

    Google Scholar 

  • Dietz, N. et al. Enhanced recovery after surgery (ERAS) for spine surgery: A systematic review. World Neurosurg. 130, 415–426. (2019).

    Article 
    PubMed 

    Google Scholar 

  • link

    Leave a Reply

    Your email address will not be published. Required fields are marked *